Recommended on Univadis

Mutations Associated with Acquired Resistance  to PD-1 Blockade in Melanoma
  • The New England Journal of Medicine
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Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

Whole-exome sequencing was performed on four patients’ tumors before exposure to pembrolizumab and after disease progression following a response to treatment.

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AAP: eliminate nonmedical immunization exemptions for school entry

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  • Clinical Essentials from N Engl J Med
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CPAP adds nothing to usual care for preventing CV events

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  • Clinical Essentials from Liver Int
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Intermediate HCC: curative therapy tops TACE for survival

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  • Clinical Essentials from Bone
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Osteoporosis: fractures at many sites in elderly men are linked to a few specific bone measures

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  • Clinical Essentials from Drugs Aging
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Heart failure: yes, hitting optimal dose targets with ACEI/ARBs in elderly patients is important

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  • Clinical Essentials from Pediatrics
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AAP survey: vaccination refusal on the rise

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  • Clinical Essentials from JAMA Intern Med
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Antidepressant treatments may be missing the mark

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  • Clinical Essentials from Circ Cardiovasc Qual Outcomes
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Does tight glycemic control really benefit people with type 2 diabetes?

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Professional Essentials

  • US Professional News
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FDA requiring boxed warning about serious risks and death when opioid pain or cough medicines combined with benzodiazepines

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  • Patients Will Be Asking
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Is there a positive side to screen time in children?

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  • Patients Will Be Asking
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Aren’t LBGT people “born that way?”

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  • US Professional News
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Obama Administration addresses concerns over ACA premium hikes

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  • US Professional News
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Clinical trial doctors seek exclusive access to the data they generate

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  • US Professional News
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Florida Supreme Court: Physicians can be held accountable if their patients commit suicide

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New on Univadis

  • Univadis
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HCV-TARGET: real-life data confirm LDV/SOF efficacy in HCV-1

Findings reveal 4 factors predictive of SVR12, high utility for an 8-wk regimen.

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  • Clinical Essentials from BJU Int
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Prostate cancer: metabolic syndrome masks serum PSA levels

The effect should be considered during prostate cancer screening.

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  • Clinical Essentials from J Subst Abuse Treat
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Adolescent alcohol abuse: why parents’ drinking is important

Tailor adolescent alcohol interventions according to demographic, psychological, and sociocontextual risk factors.

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  • Clinical Essentials from Cancer Epidemiol
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Depression may interfere with healthcare in cancer patients

The first study to show this effect in adult cancer survivors.

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  • Clinical Essentials from Circulation
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Optical coherence tomography enhances PCI success

Using OCT instead of fluoroscopy alone resulted in procedural changes in 50% of patients.

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  • Clinical Essentials from JAMA Pediatrics
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Pediatric thyroid disease: do you know the telltale signs and symptoms?

Failure to treat thyroid disorders in children promptly may compromise growth and development.

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  • Clinical Essentials from Hosp Pract
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COPD: malnutrition risk high in patients hospitalized for acute exacerbation

Nearly 1 in 4 patients are at risk for malnutrition, which is linked to poorer outcomes during and after hospitalization.

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  • Clinical Essentials from PLoS One
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Rotavirus genotypes and vaccine effectiveness from 3 consecutive rotavirus seasons in a middle income country

In low income countries rotavirus infection carries significant morbidity and mortality.

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  • Clinical Essentials from J Clin Psychiatry
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Substance use: adolescent bipolar disorder ups the risk

Monitor youth with BPD closely for smoking and substance use.

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  • Clinical Essentials from Lancet HIV
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Integrase inhibitors as effective as PIs to suppress HIV in women

Most data on HIV treatment effectiveness is based on studies in men.

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  • Clinical Essentials from Am J Sports Med
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Knee osteoarthritis: bone marrow concentrate no better than placebo

Bone marrow injections appear safe but ineffective.

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  • Clinical Essentials from J Environ Res Public Health
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Is there a better way to diagnose DKA?

Beta-hydroxybutyrate represents about 75% of the total ketones formed in the blood during DKA.

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  • Clinical Essentials from Eur Heart J
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Benefit of adding ezetimibe to statins is boosted in patients with previous CABG

Results support intensive therapy with dual lipid-lowering drugs in high-risk patients.

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  • Clinical Essentials from Ann Thorac Surg
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From MI to CABG: How long should the interval be?

Waiting 1-2 d yielded no mortality difference from waiting 3-7 d.

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