Recommended on Univadis

  • Clinical Essentials from Sci Rep
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NSCLC: therapeutic vaccines, immune checkpoint inhibitors improve survival

Agents that stimulate specific anti-tumor immune response appear to have superior efficacy.

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  • Clinical Essentials from J Thromb Haemost
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PT, aPTT values aren’t great indicators of direct oral anticoagulant effectiveness

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  • Clinical Essentials from JAMA Intern Med
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Antidepressant treatments may be missing the mark

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  • Clinical Essentials from Pediatrics
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AAP survey: vaccination refusal on the rise

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  • Clinical Essentials from Circ Cardiovasc Qual Outcomes
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Does tight glycemic control really benefit people with type 2 diabetes?

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  • Clinical Essentials from Drugs Aging
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Heart failure: yes, hitting optimal dose targets with ACEI/ARBs in elderly patients is important

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  • Clinical Essentials from N Engl J Med
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R/R multiple myeloma: daratumumab-based regimen delivers deep, rapid, and durable response

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  • Clinical Essentials from J Clin Oncol.
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FL: baseline total metabolic tumor volume predicts early progression

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  • Clinical Essentials from N Engl J Med
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Early-stage breast cancer: novel 70-gene signature predicts chemotherapy benefit

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Professional Essentials

  • Patients Will Be Asking
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Bar soap is gross, right?

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  • Patients Will Be Asking
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How can I get my loved one to seek depression treatment?

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  • US Professional News
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Implementation of MACRA may endanger viability of small and solo practices

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  • US Professional News
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Children on public insurance may be treated differently during ER visits

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  • US Professional News
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Many Americans would self-prescribe antibiotics if allowed

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  • US Professional News
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Rural hospitals struggle to adapt to contemporary health policy environment

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New on Univadis

  • Clinical Essentials from Cancer
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Rectal cancer: adjuvant chemotherapy improves survival

The value of adjuvant chemotherapy after neoadjuvant chemoradiation and curative resection remains unclear.

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  • Clinical Essentials from JAMA Otolaryngol Head Neck Surg
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Oral cancer: no survival benefit from neck dissection in cN0 dosease

Identifying node-negative patients who will benefit from prophylactic neck treatment is challenging.

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  • Clinical Essentials from Acta Oncol
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CP-CML: newer TKIs outperform imatinib in molecular response but not survival

More complete molecular responses, but with no clear difference in all-cause mortality.

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  • Clinical Essentials from JAMA Oncol
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Prostate cancer: number of docetaxel cycles independently linked to survival

Mainsail data showed a median survival of 33 mo with ≥10 cycles vs 23 mo with 5-7 cycles.

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  • Clinical Essentials from Alcohol Alcohol
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Alcohol dependence treatment: the predictive value of early abstinence

Failure to achieve early abstinence may be a useful marker.

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  • Clinical Essentials from Am J Med
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Hospital sleep: simple instruction improves sleep enhancement tools

Patient education is a simple step that has the potential to improve sleep in hospital settings.

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  • Clinical Essentials from Lancet HIV
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Children with HIV: EFV-free weekends as effective as ongoing ART at 48 w

People with HIV must spend a lifetime on treatment but are prone to drug resistance.

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  • Clinical Essentials from Lancet Neurol
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Stroke: adding mechanical thrombectomy to standard IVT improves functional independence

IVT is standard treatment for stroke, but less effective for large vessel occlusions.

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  • Clinical Essentials from Eur J Cancer Prev
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Smoking linked to 25% increased risk for gastric cancer

Data from the StoP project quantify the relationship between smoking and gastric cancer.

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  • Clinical Essentials from MMWR Morb Mortal Wkly Rep
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Zika transmitted sexually from asymptomatic male partner warrants new testing considerations

Lack of symptoms does not preclude risk.

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  • Clinical Essentials from J Periodontol
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Dental implants: prophylactic dexamethasone equal to ibuprofen for post-op pain

Few randomized controlled studies have provided a direct comparison of prophylactic strategies.

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  • Clinical Essentials from Neurology
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Nasogastric tubes appear safe in patients with stroke

Dysphagia is often managed with NGTs, but there is conflicting data that NGTs may increase pneumonia risk.

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  • Clinical Essentials from Epidemiology
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Does late-life cognitive activity delay or prevent dementia?

Clinicians should advise elderly patients to participate in cognitive activities of their choice.

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  • Clinical Essentials from Eur J Paediatr Neurol
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Dystonia: treating children with DBS – a 10-y review

Is deep brain stimulation a good choice for children with dystonia?

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