Recommended on Univadis

Whether addition of bevacizumab to first-line therapy with letrozole improved progression-free survival in hormone receptor–positive advanced breast cancer?
  • Journal of Clinical Oncology
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Whether addition of bevacizumab to first-line therapy with letrozole improved progression-free survival in hormone receptor–positive advanced breast cancer?

The addition of bevacizumab to letrozole improved progression-free survival in hormone receptor–positive metastatic breast cancer, but this benefit was associated with a markedly increased risk of grade 3 to 4 toxicities. Research on predictive markers will be required to clarify the role of bevacizumab in this setting.

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  • Clinical Essentials from Abdom Radiol (NY)
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Prostate cancer: in-bore magnetic resonance-guided biopsy shows high yield for significant disease

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  • Clinical Essentials from Arch Pathol Lab Med.
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Nonmelanoma skin cancer: consider biopsy margin reports with caution

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  • Clinical Essentials from N Engl J Med.
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Multiple myeloma: phase 3 results for ixazomib regimen in relapsed/refractory patients

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  • Clinical Essentials from PLoS One.
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Metastatic melanoma: what’s the best platform for BRAF mutation detection?

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  • Clinical Essentials from Morb Mortal Wkly Rep
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Zika hitting hard in Puerto Rico: CDC

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  • Clinical Essentials from N Engl J Med
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Ebola vaccine yields greater response with modified Ankara booster strain

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  • Clinical Essentials from Photodiagnosis Photodyn Ther.
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Basal cell carcinoma: adjunct OCT examination improves detection of recurrent lesions

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  • Clinical Essentials from Prostate Cancer Prostatic Dis
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Prostate cancer: early cessation of radium-223 linked to baseline epidural disease

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Professional Essentials

  • Patients Will Be Asking
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Will mindfulness therapy help my depression?

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  • Patients Will Be Asking
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What can I do with my old prescriptions?

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  • US Professional News
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Trio of major hospital networks announces controversial “volume pledge” for high-risk surgical procedures

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  • US Professional News
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Insurance plans offered on ACA marketplaces face coming price hikes

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  • US Professional News
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Volume-outcome relationship may not hold for all complex surgical procedures

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  • US Professional News
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CMS allows Medicaid managed care plans to include telemedicine services in provider networks

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New on Univadis

Fireworks-related burns requiring hospital stays increased among children | PAS
  • Conference Essentials
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Fireworks-related burns requiring hospital stays increased among children | PAS

The proportion of injuries requiring inpatient admission rose from 28.9% in 2006 to 50.0% in 2012.

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Percentage of US children with chronic health conditions on rise  | PAS
  • Conference Essentials
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Percentage of US children with chronic health conditions on rise | PAS

Among children with public health insurance, significant increases were seen among all the chronic diseases studied.

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Alcohol advertising on TV linked to teens' brand preferences and drinking behaviors | PAS
  • Conference Essentials
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Alcohol advertising on TV linked to teens' brand preferences and drinking behaviors | PAS

At 12%, Budweiser was far and away the most frequently occurring brand placement.

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  • Clinical Essentials from Oncotarget
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Dietary fat intake is linked to ovarian cancer and distinct subtypes: A meta-analysis

Previous meta-analyses have reported conflicting results, so this one analyzed more case-control studies and examined fat types and ovarian cancer subtypes

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  • Clinical Essentials from Br J Surg
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Colorectal cancer risk increased after oophorectomy

Colorectal cancer is influenced by hormonal factors, but whether oophorectomy, which alters endogenous levels of sex hormones, has an effect on risk for colorectal cancer is unclear.

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  • Clinical Essentials from Eur J Nucl Med Mol Imaging
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PTC prognosis linked to incomplete surgical clearance of LNM

Initial nodal involvement is associated with higher recurrence rates.

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  • Clinical Essentials from J Urol
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Prostate cancer: irreversible electroporation prostate gland ablation safe and feasible

The majority of men had no evidence of residual cancer on biopsy 6 mo after prostate gland ablation.

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  • Clinical Essentials from J Surg Oncol
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Metastatic CRC: local control of primary lesions improves prognosis

Controlling the primary lesions in metastatic colorectal cancer through resection or irradiation remains controversial.

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  • Clinical Essentials from Cancer Med.
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Pediatric ALL: are parental behaviors linked to sleep disturbances?

Study suggests parental cosleeping is an ineffective strategy.

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  • Clinical Essentials from PLoS Med
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New HCC prognostic system: the best yet?

There is no universal prognostic system for HCC, and existing systems often lack prognostic power or are difficult to use in clinical practice.

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Effect of aliskiren on renal outcomes in patients with type 2 diabetes
  • The Lancet Diabetology
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Effect of aliskiren on renal outcomes in patients with type 2 diabetes

Aliskiren delayed disease progression to microalbuminuria and macroalbuminuria, and improved regression of albuminuria, but did not show beneficial effect on hard renal outcomes

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  • Clinical Essentials from Eur J Cardiothorac Surg
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NSCLC metastasis predicted by PET/CT findings

Predictors of occult metastases might help guide treatment decisions.

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  • Clinical Essentials from Arthritis Rheumatol
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Glucocorticoid-induced osteoporosis: teriparatide has greater impact than alendronate

How would you treat glucocorticoid-induced osteoporosis?

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  • Clinical Essentials from Breast Cancer Res Treat
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Breast cancer: adiposity, dysmetabolism, and inflammation are linked to aggressive breast cancer subtypes

It is well known that obesity and metabolic syndrome are risk and prognostic factors for breast cancer and are associated with inflammation, but the association of adiposity, dysmetabolism and inflammation is not well-studied in relation to aggressive breast cancer subtypes

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