Recommended on Univadis

  • Clinical Essentials from J Clin Oncol
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Breast cancer: perindopril, bisoprolol may prevent trastuzumab-mediated cardiotoxicity

Randomized controlled trial shows that cardiac drugs attenuate trastuzumab-mediated decline in LVEF.

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  • Clinical Essentials from Eur Urol
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Clear-cell RCC: 43% of metastatic tumors differ from primary subtype

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  • Clinical Essentials from JAMA Psychiatry
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Childhood depression: what precedes it?

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  • Clinical Essentials from Diabetes Care
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Which insulin regimen best minimizes glycemic variability?

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  • Clinical Essentials from J Clin Lipidol
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More patients need high-dose statin therapy

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  • Univadis
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HPV vaccine uptake: clinician annoucements top open-ended conversations

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  • Clinical Essentials from Neurology
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Multiple sclerosis associated with low vitamin D levels at birth

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  • Clinical Essentials from Obes Surg
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Low-dose aspirin appears safe after gastric bypass

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  • Clinical Essentials from Fertil Steril
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Postmenopausal women with hypoactive sexual desire disorder: testosterone may help

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Professional Essentials

  • US Professional News

Patients who choose doctors with lower-priced office visits save hundreds per year, study suggests

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  • US Professional News

Hospitals and physician groups frequently demand payment from patients up front

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  • US Professional News

ACA repeal could raise number of insured by 30 million people, report suggests

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  • US Professional News

Depression is a common problem for medical students, new research suggests

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  • Patients Will Be Asking

Should I try harder to be optimistic?

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  • Patients Will Be Asking

Are my kid’s headphones too loud?

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New on Univadis

  • Clinical Essentials from Oncotarget
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Bladder cancer: cancer-specific mortality 20% higher in former smokers

This is the first systematic epidemiologic assessment of the association between smoking status and prognosis.

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  • Clinical Essentials from Langenbecks Arch Surg
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Advanced gastric cancer: type-4 and diffuse-type tumors predict peritoneal spread

Use of staging laparoscopy based on preoperative clinicopathologic factors in advanced gastric cancer is controversial.

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  • Clinical Essentials from Oncotarget
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SCLC: should angiogenesis inhibitors be added to chemotherapy?

Meta-analysis shows improved response and survival outcomes vs chemotherapy alone.

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  • Clinical Essentials from Clin Neurophysiol
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Sleep EEG important for infants with congenital Zika virus syndrome

Infants with congenital Zika syndrome have distinct sleep abnormalities.

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T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer
  • The New England Journal of Medicine
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T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer

There was regression of metastatic colon cancer followed by immune evasion of one lesion after the adoptive transfer of T cells specifically targeting mutant KRAS.

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Thyroid Disease: Monthly Essentials December 2016
  • Monthly Essentials
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Thyroid Disease: Monthly Essentials December 2016

Thyroid cancer increasing | Thyroid levels and gestational diabetes | Hypothyroidism and sleep apnea

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  • Clinical Essentials from Female Pelvic Med Reconstr Surg
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IBS assessment important for women with fecal incontinence

IBS affects one-third of women presenting to tertiary care centers with fecal incontinence.

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  • Clinical Essentials from Vaccine
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Pneumococcal and influenza vaccines: coadministration is safe, effective

Concomitant administration is an efficient strategy to increase vaccine uptake.

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  • Clinical Essentials from J Rheumatol
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Rheumatoid arthritis: phase 2 response with B-cell-targeting SBI-087 is modest

B cell depletion remains an area of drug development interest.

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  • Clinical Essentials from Reg Anesth Pain Med
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Cervical steroid injection: targeted epidural catheter equal to standard C7-T1 interlaminar approach

This is the first study to directly compare the two approaches.

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  • Clinical Essentials from J Rheumatol
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Rheumatoid arthritis: 5 y of tocilizumab monotherapy can be safe and effective

Biologic monotherapy can still be effective when methotrexate or other conventional synthetic DMARDs fail.

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  • Clinical Essentials from Chest
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COPD: Bevespi Aerosphere tops single-agent MDIs

PINNACLE studies 1 and 2 served as the basis for FDA approval in April 2016.

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  • Clinical Essentials from Arthritis Rheumatol
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Tofacitinib treatment in RA leads to significant remission rates by variety of measures

In RA, gauge used to measure remission affects clinical trial analysis.

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  • Clinical Essentials from BMJ
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Vitamin D studies are inconclusive for most conditions

Vitamin D supplementation questioned in BMJ review.

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