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  • Clinical Essentials from Cancer Treat Rev
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Prostate cancer: drug interactions with abiraterone, enzalutamide

Enzalutamide may cause more drug-drug interactions than abiraterone.

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  • Vitals
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Primary Care Oncology Vitals for March 2017

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  • Clinical Essentials from Stroke
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Stroke: data support transfer to high-volume center after EVT

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  • Clinical Essentials from https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm549078.htm?source=govdelivery&utm_medium=email&utm_source=govdelivery
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FDA approves first biologic for atopic dermatitis

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  • Clinical Essentials from Natl Health Stat Report
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CDC releases FRAX estimates for fracture in US adults ≥40

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  • Clinical Essentials from Ann Rheum Dis
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Modest alcohol consumption during methotrexate therapy safe in RA

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  • Clinical Essentials from Am J Respir Crit Care Med
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Incremental hourly delays in antibiotic administration in sepsis linked to increased mortality

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  • Clinical Essentials from Am J Psychiatry
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Depression: treatment preference may not matter

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  • Clinical Essentials from Am J Cardiol
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Coronary artery disease prevalent in young type 2 diabetes patients

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Professional Essentials

  • US Professional News

California physicians get new star rating system

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  • US Professional News

Medical students draw comics to express angst

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  • US Professional News

Survey confirms physicians' enmity toward DTC ads

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  • US Professional News

Texas physician could face prison in Medicare scheme

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  • US Professional News

Fake physician convicted in mystery butt injections

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Physician burnout a "public health crisis"

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New on Univadis

Hypothyroidism: epidemiology, diagnosis and management
  • The Lancet
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Hypothyroidism: epidemiology, diagnosis and management

Hypothyroidism diagnosed easily, but could be fatal in some severe cases if remain untreated

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  • Clinical Essentials from FDA
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FDA approves ocrelizumab for relapsing, primary progressive forms of MS

This is the first drug to be approved for primary progressive MS.

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  • Clinical Essentials from J Am Geriatr Soc
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Pneumonia linked to proton pump inhibitors in dementia patients

Physicians should exercise caution when prescribing PPIs to patients with dementia.

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  • Clinical Essentials from Transpl Int
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HCV+ kidneys: posttransplant DAA therapy widens donor pool

Study shows 96% clearance rate in HCV+ patients receiving HCV+ kidneys.

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  • Clinical Essentials from Eur J Cancer
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Breast cancer diagnosed with brain metastases: what factors predict survival?

Results of a SEER analysis.

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  • Clinical Essentials from JAMA Oncol
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GIST: which genotype benefits most from extended use of adjuvant imatinib?

A 3-y course reduces recurrence risk in tumors with KIT exon 11 deletion mutations.

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  • Clinical Essentials from Br J Haematol
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RFND regimens deliver long-term survival in indolent lymphoma

Results at more than 12 y of follow-up.

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  • Clinical Essentials from Cancer
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HPV+ OPSCC: extranodal extension linked to poorer survival

Adjuvant CRT shows no added benefit vs RT alone.

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Low BMD is a major contributor to global health burden from traffic accidents | WCO
  • Conference Essentials
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Low BMD is a major contributor to global health burden from traffic accidents | WCO

These findings are a cause for urgent attention, said the study authors.

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  • Clinical Essentials from Viral Hepat
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HCV: DAAs highly effective among injection drug users

Data from a real-world prospective study.

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  • Clinical Essentials from J Affect Disord
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Depression in HIV: single and dual-action agents similarly effective

Remission is uncommon with either treatment.

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Vaginal prostaglandin as efficient as oxytocin for induction of labor in women with prelabor rupture of membranes at term | RCOG
  • Conference Essentials
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Vaginal prostaglandin as efficient as oxytocin for induction of labor in women with prelabor rupture of membranes at term | RCOG

Early delivery will reduce maternal and fetal infection and the need for antibiotics for newborn.

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  • Clinical Essentials from J Orthop Surg Res
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THA and TKA: pregabalin cuts post-op pain within the first 48 h, not later

Results of a meta-analysis also show less opioid use.

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  • Clinical Essentials from Crit Care
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qSOFA has greater discriminatory ability for in-hospital mortality in pre-ICU patients with sepsis

Clinicians treating patients with suspected sepsis may wish to use qSOFA scores to direct early clinical management

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