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News

Today’s most essential news for your practice, in time-saving summaries.

FDA approves venetoclax-obinutuzumab for frontline CLL, SLL

Approval realizes a chemo-free, fixed-duration treatment option.

May 21, 2019

Kanuka honey, acyclovir similarly effective for cold sores

A randomized controlled trial.

May 21, 2019 -

BMJ Open

Alpelisib delays progression in PIK3CA+ advanced breast cancer

SOLAR-1 phase 3 data may lead to alpelisib approval.

May 21, 2019 -

N Engl J Med

Mild asthma: budesonide-formoterol as needed outperforms albuterol

On-demand inhaled steroids also led to fewer exacerbations than maintenance steroids.

May 21, 2019 -

N Engl J Med

Cervical cancer: no survival benefit for ACT after concurrent chemoradiation

May 21, 2019 -

J Gynecol Oncol

NSCLC: adding bevacizumab ups survival with carboplatin-pemetrexed

May 21, 2019 -

J Natl Compr Canc Netw

CRC: BMI shows little utility for assessing cardiovascular risk

May 21, 2019 -

JAMA Oncol

Resected PDAC: study identifies optimal cutoff for early vs late recurrence

May 21, 2019 -

Ann Surg

Salvage head/neck surgery: medical complications more deadly than surgical

May 21, 2019 -

Oral Oncol

Breast cancer: TP53 status determines effects of estrogen receptor

May 21, 2019 -

J Natl Cancer Inst

Medical abortion can be safely extended to 70 days

May 20, 2019 -

Contraception

In IBD, extended opioid use linked to emergent encounters, higher costs

May 20, 2019 -

Inflamm Bowel Dis

Asymptomatic OSA linked to distinct pattern on memory screening tool

May 20, 2019 -

WMJ

FDA approves avelumab-axitinib for frontline RCC

May 20, 2019

Panel advises against hormone treatment for mild hypothyroidism

May 20, 2019 -

BMJ

Osteoarthritis: resistance training offers best nondrug pain relief for elders

May 20, 2019 -

Am J Phys Med Rehabil

FDA warns against use of unauthorized devices for DM management

May 20, 2019 -

FDA

Chlamydia pneumoniae severity correlates with CHD severity, prognosis

May 20, 2019 -

BMC Cardiovasc Disord

Hormones tied to increased breast cancer risk in trans women, men

May 20, 2019 -

BMJ

Lipid checks boost statin adherence among patients with ASCVD

May 20, 2019 -

Am J Med

X-linked hypophosphatemia: burosumab bests conventional therapy

May 20, 2019 -

Lancet

Skin disease: 7.8% rehospitalized for same diagnosis within a year

May 20, 2019 -

J Am Acad Dermatol

Sepsis: which survivors have highest stroke, MI risk?

May 20, 2019 -

J Intensive Care Med

ALS: tirasemtiv falls short, but mechanism shows promise

May 20, 2019 -

Amyotroph Lateral Scler Frontotemporal Degener

Arrhythmogenic cardiomyopathy: multiple societies issue guideline

May 20, 2019 -

Heart Rhythm

Acute heart failure: malnutrition linked to 3-fold short-term mortality risk

May 20, 2019 -

Eur J Intern Med

Gastric cancer: HIPEC + cytoreductive surgery improves survival

May 20, 2019 -

J Clin Oncol

Early NSCLC: SBRT shows survival advantage over ablation procedures

May 20, 2019 -

J Natl Compr Canc Netw

Oral cancer: 3 factors for time to recurrence, 4 for survival

May 20, 2019 -

Oral Oncol

AML: can cytokines be leveraged to treat cancer-related fatigue?

May 20, 2019 -

J Geriatr Oncol

FDA approves blood thinner for pediatric VTE

May 17, 2019 -

FDA

Acne: 5-component cream shows benefit in pilot study

May 17, 2019 -

Clin Cosmet Invetig Dermatol

Buprenorphine tops naltrexone for reducing opioid overdose risk

May 17, 2019 -

Drug Alcohol Depend

Intrapartum glucose monitoring in GDM: tight glycemic control offers little benefit

May 17, 2019 -

Obstet Gynecol

Ischemic stroke: younger patients more likely to receive thrombolysis, but with longer delay

May 17, 2019 -

Neurology

Zoster vaccine shows benefit in reducing postherpetic neuralgia

May 17, 2019 -

Vaccine

Roux-en-Y carries higher fracture risk than banding

May 17, 2019 -

JAMA Surg

Syncope during pregnancy is associated with preterm birth, future cardiac disease

May 17, 2019 -

J Am Heart Assoc

ESMO guideline now includes FLOT for gastric cancer

May 17, 2019 -

European Society for Medical Oncology

NKF 2019—Polycystic kidney disease: Tolvaptan is safe for statin users

May 17, 2019

HCV: SOF/VEL yields 99% clearance rate regardless of fibrosis stage

May 17, 2019 -

PLoS One

WHO: a healthy lifestyle helps reduce risk for cognitive decline, dementia

May 17, 2019 -

World Health Organization

Uterine rupture: timing of diagnosis affects maternal outcomes

May 17, 2019 -

J Matern Fetal Neonatal Med

Early breast cancer: nab-paclitaxel prolongs time to invasive disease

May 17, 2019 -

J Clin Oncol

Multiple myeloma: pomalidomide-based triplet reduces progression

May 17, 2019 -

Lancet Oncol

Metastatic kidney cancer: frontline atezolizumab-bevacizumab tops sunitinib in phase 3

May 17, 2019 -

Lancet

For critically ill adults, vitamin C supplementation offers no mortality benefit

May 17, 2019 -

Crit Care Med

Primary sclerosing cholangitis does not respond to vedolizumab

May 17, 2019 -

Clin Gastroenterol Hepatol

Pediatric elbow fracture readily detectable by POCUS

May 17, 2019 -

Ann Emerg Med

Bariatric surgery linked to higher survival after MI or CVA

May 17, 2019 -

Diabetes Obes Metab

Professional News

Essential news on the business and practice of medicine, in time-saving summaries.

Physician practices can be an easy target for cybercriminals

May 20, 2019

Antivaccine activists target provaccine doctors

May 20, 2019

When are you too old to operate? Group publishes new guidelines

May 20, 2019

New liver distribution system put on hold

May 20, 2019

More Professional News

Quiz

1-minute quiz: Test your knowledge with today’s question.

Endocrine Society guidelines for hip fracture prevention

What is first-line therapy?

May 21, 2019

MI: More or less deadly than 20 years ago?

May 20, 2019

Diagnosing appendicitis in adults

May 17, 2019