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News

Today’s most essential news for your practice, in time-saving summaries.

ESMO 2018 – Adding atezolizumab to chemotherapy prolongs survival in PD-L1 positive metastatic triple-negative breast cancer

Trial establishes new standard of care for these poor-prognosis patients

October 22, 2018

ESMO 2018 – Training oncologists increases use of shared decision-making around palliative systemic treatment

The effect of oncologist and patient training was evaluated in a randomised controlled trial

October 22, 2018

ESMO 2018 – Differential effects of local radiotherapy in metastatic prostate cancer, depending on disease burden

In the STAMPEDE trial, radiotherapy to the prostate improved overall survival in men, but only if the tumour burden was low

October 22, 2018

ESMO 2018 – Is neoadjuvant erlotinib ready for centre stage in early mutated non-small cell lung cancer?

A phase 2 study from China demonstrated superiority in progression-free survival for erlotinib over gemcitabine plus cisplatin in the neoadjuvant...

October 22, 2018

ESMO 2018 – Triple therapy as first-line treatment of BRAF-mutant advanced melanoma: combination matters

October 22, 2018

ESMO 2018 – Do males and females with oesophagogastric cancer experience chemotherapy efficacy or toxicity differently?

October 22, 2018

FDA approves talazoparib for BRCA+, HER2-negative breast cancer

October 22, 2018

Timing of postpartum IUD placement: it's complicated

October 22, 2018 -

Obstet Gynecol

For HFrEF, home-based rehabilitation improves QoL: REACH-HF

October 22, 2018 -

Eur J Prev Cardiol

NCCN Insights focus on SCLC pathology, radiation therapy

October 22, 2018 -

J Natl Compr Canc Netw

Cochrane: chemohormonal therapy tops ADT alone in metastatic PCa

October 22, 2018 -

Cochrane Database Syst Rev

Cochrane review: prokinetics of uncertain benefit for functional dyspepsia

October 22, 2018 -

Cochrane Database Syst Rev

For pediatric ambulance patients, this tool predicts deterioration

October 22, 2018 -

Resuscitation

COPD exercise endurance improves best with holistic approach: PHYSACTO

October 22, 2018 -

Am J Respir Crit Care Med

Diabetes: metformin tied to lower risk for gastric cancer

October 22, 2018 -

J Natl Cancer Inst

CML-CP: assessing the ongoing burden of AEs with 2G, 3G TKIs

October 22, 2018 -

Cancer Med

HNSCC: Dutch study evaluates utility of 18F-FDG-PET/CT, DWI after RT/CT

October 22, 2018 -

Clin Oncol (R Coll Radiol)

ESMO 2018 – Global health status, quality of life data favour talazoparib in patients with triple negative breast cancer and BRCA1/2 mutations

October 21, 2018

ESMO 2018 – The value of adding bevacizumab to carboplatin/pegylated liposomal doxorubicin when treating recurrent ovarian cancer

October 21, 2018

ESMO 2018 – Can advances in metastatic NSCLC be transferred to early-stage disease?

October 21, 2018

ESMO 2018 – Using cabazitaxel before androgen receptor therapy may maximise clinical benefit in poor prognosis mCRPC

October 21, 2018

ESMO 2018 – Reduced mortality, relapses for sarcoma patients in French reference centre

October 21, 2018

ESMO 2018 – Adding ribociclib to fulvestrant maintains quality of life in advanced breast cancer

October 20, 2018

ESMO 2018 – Adding radium-223 to abiraterone associated with poorer outcomes in mCRPC

October 20, 2018

ESMO 2018 – One in six premenopausal breast cancer patients inadequately adherent to tamoxifen after one year

October 20, 2018

ESMO 2018 – Tepotinib+gefitinib, a promising combination therapy in MET+/EGFR-mutant non-small cell lung cancer

October 20, 2018

ESMO 2018 – Synthetic peptides hit three targets simultaneously in recurrent glioblastoma

October 20, 2018

5-FU adds benefit to triamcinolone for keloids, hypertrophic scars

October 19, 2018 -

Burns

Thyroid ultrasound tied to increased diagnosis of low-risk cancer

October 19, 2018 -

J Clin Endocrinol Metab

Abortion "reversal" legislation and science clash

October 19, 2018 -

N Engl J Med

Aspirin ineffective for preventing dementia, disability in healthy older adults

October 19, 2018 -

N Engl J Med

Rapid opt-out HIV screening boosts uptake in young people

October 19, 2018 -

Pediatrics

Depression: adjunctive atypical antipsychotics have limited use

October 19, 2018 -

Bipolar Disord

Structural brain abnormalities seen in prediabetes

October 19, 2018 -

Diabetes Care

HLA genotyping isn’t useful for celiac screening in T1D

October 19, 2018 -

Arch Dis Child

TKA: aspirin, other anticoagulants similar for VTE prevention

October 19, 2018 -

JAMA Surg

Advanced melanoma: adding ziv-aflibercept to IL-2 boosts PFS

October 19, 2018 -

Cancer

Bladder cancer: no survival advantage for extended vs limited LND in German study

October 19, 2018 -

Eur Urol

3D screening mammography detects 34% more breast cancers

October 19, 2018 -

Lancet Oncol

GOP senator sought "brain frequency" treatment for vets

October 19, 2018

Abuse affects a woman's risk for preterm delivery, low-birth-weight children

October 19, 2018 -

BMC Pregnancy Childbirth

Preeclampsia is a risk factor for Alzheimer's, other dementias

October 19, 2018 -

BMJ

Naloxone for opioid-exposed newborns: 5 years, 1 opioid epidemic, nothing has changed

October 19, 2018 -

Cochrane Database Syst Rev

Ibuprofen does not impair semen quality

October 19, 2018 -

J Assist Reprod Genet

Opioid, benzodiazepine misuse tied to suicidal thinking in elders

October 19, 2018 -

Int J Geriatr Psychiatry

Cirrhosis: opioid prescribing on the rise among veterans

October 19, 2018 -

Clin Gastroenterol Hepatol

CRC screening boosted with FBT outreach, patient navigators

October 19, 2018 -

JAMA Intern Med

R/R CLL/SLL: updated results for the phase 3 HELIOS study

October 19, 2018 -

Leukemia

Postmastectomy RT: chest wall symptoms affect QoL in UK SUPREMO

October 19, 2018 -

Lancet Oncol

HCV: can serum markers replace TE for estimating fibrosis, cirrhosis?

October 19, 2018 -

J Viral Hepat

Professional News

Essential news on the business and practice of medicine, in time-saving summaries.

Hospital says late endocrinologist may have abused patients

October 19, 2018

GOP senator sought "brain frequency" treatment for vets

October 19, 2018

Apple pursuing patient monitoring beyond its watch EKG

October 19, 2018

More Professional News

Quiz

1-minute quiz: Test your knowledge with today’s question.

New evidence for effects of ART

Long-term outcomes?

October 22, 2018

A cochlear migraine?

October 19, 2018

Image Quiz: Obese man with HTN, dyspnea on exertion, and heart palpitations

October 18, 2018