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ASCO 2017 - Relapsed/refractory diffuse large B-cell lymphoma: JCAR017 achieves high CR rates in phase 1 trial

No severe cytokine release syndrome at the lower dose.

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ASCO 2017 - Metastatic castration-resistant prostate cancer: indoximod after sipuleucel-T boosts PFSl in phase 2 trial

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ASCO 2017 - Relapsed/refractory multiple myeloma: LCAR-B38M yields 100% ORR in phase 1 trial

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ASCO 2017 - NHL: 82% ORR with axicabtagene ciloleucel in phase 1/2 ZUMA-1 trial

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ASCO 2017 - Advanced SCLC: promising results with nivolumab±ipilimumab

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ASCO 2017 - Melanoma brain mets: nivolumab+ipilimumab deliver promising phase 2 results

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ASCO 2017 - High-risk breast cancer: pembrolizumab+standard therapy improved pathologic complete response rates

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ASCO 2017 - NSCLC: phase 3 study suggests prolonged survival benefit with atezolizumab

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ASCO 2017 - Extensive-stage SCLC after chemotherapy: favorable OS with pembrolizumab in phase 2 trial

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Professional Essentials

  • US Professional News

Senate health bill includes cuts to Medicaid

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PCPs: fickle millennials may move on

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  • US Professional News

MACRA reporting eased in proposal

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  • US Professional News

AMA campaign aimed at easy MIPS compliance

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  • Patients Will Be Asking

Can I get a "gentle" cesarean?

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  • US Professional News

American Medical Association delegates push for MOC credit

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New on Univadis

  • Clinical Essentials from JAMA Intern Med
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CRC: meta-analysis supports diagnostic FIT in high-risk patients

Accuracy for advanced cases is not as good, however.

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  • Clinical Essentials from Scand J Pain
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THA: local infiltration analgesia tops femoral nerve block for post-op pain

Results of a randomized, double-blind study.

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  • Clinical Essentials from Arthritis Rheumatol
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RA: elderly patients are getting a lot of opioid prescriptions

Especially if they are black or have back pain.

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  • Clinical Essentials from Arthritis Care Res (Hoboken)
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RA: fish-eating patients might do better

Clinically significant differences in disease scores in frequent vs infrequent fish eaters.

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  • Clinical Essentials from JAMA
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3 of every 100 US adults takes way too much vitamin D

The number overdoing vitamin D has increased since 1999.

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  • Clinical Essentials from Ann Oncol
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MCRC: less hand-foot syndrome with S-1 vs capecitabine

Data from the phase 3 SALTO trial show reduced incidence, severity.

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  • Clinical Essentials from MMWR Morb Mortal Wkly Rep
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CDC: chronic Lyme disease treatments tied to serious infections

Overdiagnosis of chronic Lyme based on clinical suspicion alone is a growing problem.

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  • Clinical Essentials from Chest
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Chest Expert Cough Panel: recommendations on chronic cough in children

The most common etiologies vary according to age and location.

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  • Clinical Essentials from Clin Gastroenterol Hepatol
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HCV: pre-LT DAA therapy most cost effective with lower MELD

Posttransplant treatment is more cost effective/saving with MELD over 22.

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  • Clinical Essentials from AJNR Am J Neuroradiol
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Stroke: CTA angiography tops noncontrast CT for predicting EVT outcomes

Data supports use of CTA-SI ASPECTS, which is not currently considered in EVT-eligibility guidelines.

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  • Clinical Essentials from BMJ Open
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Depression: 2nd generation antidepressants, CBT are best bets

Analysis of 19 systematic reviews.

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  • Clinical Essentials from JAMA Cardiol
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TAVR: nearly 1 in 10 procedures in the US are off-label

Off-label indications most commonly include severe aortic or mitral regurgitation.

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  • Clinical Essentials from J Diabetes Sci Technol
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How accurate are diabetes alert dogs?

Accuracy varies widely among individual dogs.

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  • Clinical Essentials from Am Health Drug Benefits
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Prostate cancer: lower CNS risk with abiraterone vs enzalutamide, chemotherapy

Reduced risk for CNS effects was independent of metastases.

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