Professional Essentials

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Are new hypertension guidelines realistic?

  • Patients Will Be Asking

Patients Will Be Asking: Why should I get a flu shot if it's only 10% effective?

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UK surgeon accused of "branding" livers

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"Die-in" protests guns in hospitals

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FDA tool helps with antibiotic prescribing

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Quality reporting efforts may be counterproductive

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New on Univadis

Second line treatments improve HRQoL in pediatric ITP | ASH
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Second line treatments improve HRQoL in pediatric ITP | ASH

Rituximab had the greatest impact in decreasing fatigue at 1 mo.

Heart Disease Vitals for December 2017
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Heart Disease Vitals for December 2017

CPR international consensus recommendations | A call for newborn CHD screening | ACC decision pathway for bleeding management with anticoagulants.

  • Clinical Essentials from J Natl Cancer Inst
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TNBC: nab-paclitaxel more effective with carboplatin than gemcitabine

WSG-ADAPT-TN randomized trial reveals higher pCR rate and fewer adverse events.

  • Clinical Essentials from Br J Dermatol
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Atopic dermatitis: long-term data support off-label methotrexate/azathioprine

Evidence for 5-year effectiveness and safety.

  • Clinical Essentials from J Am Heart Assoc
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Anticoagulant, Afib, and major noncardiac surgery generally OK together

One exception is urgent surgery.

  • Clinical Essentials from Am J Obstet Gynecol
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Trichomonas vaginalis most often detected during perimenopause

There may be increased susceptibility at later age.

HIV, hepatitis, hemorrhage most common hemophilia-related death | ASH
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HIV, hepatitis, hemorrhage most common hemophilia-related death | ASH

Hemophilia-related mortality less likely related to cardiac complications and cancer.

  • Clinical Essentials from JAMA Oncol
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Recurrent ovarian cancer: add-on pazopanib fails to show survival benefit

Adding pazopanib to paclitaxel boosts toxicity, but not survival.

Caplacizumab effective in TTP | ASH
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Caplacizumab effective in TTP | ASH

Drug showed significant improvement in time to normalization of platelet count.

  • Clinical Essentials from Lancet Respir Med
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Breathing retraining via DVD for asthma

It’s as effective as face-to-face training, and both are better than usual care.

  • Clinical Essentials from PLoS One
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Lung cancer: carboplatin, cisplatin yield similar risk for thromboembolism

Carboplatin is the preferred treatment, but thromboembolism risk was understudied.

  • Clinical Essentials from Gastroenterology
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Pancreatic cancer: no decreased risk with aspirin or NSAIDs

Data from over 141K individuals in 2 prospective cohorts shows no association.

  • Clinical Essentials from J Am Geriatr Soc
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Late-life depression outcomes linked to metabolic syndrome

Studies show mixed results in these patients.

  • Clinical Essentials from Lancet Neurol
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Parkinson's disease: specialized physiotherapy works in real-world setting

An observational cohort study of a care model used in the Netherlands.