Recommended in Infectious Diseases

  • Clinical Essentials from MMWR Morb Mortal Wkly Rep
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CDC: influenza vaccine 48% effective this season

Results of an interim analysis in the Morbidity and Mortality Weekly Report.

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  • Clinical Essentials from BMJ
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Prevention of acute respiratory infections: “a major new indication for vitamin D supplementation”

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  • Conference Essentials
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Isoniazid prophylaxis reduces mortality in African adults with high CD4 count | CROI

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  • Conference Essentials
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IL-1β inhibition significantly reduces atherosclerotic inflammation in treated HIV | CROI

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  • Clinical Essentials from Inflamm Bowel Dis
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Does maternal peripartum antibiotic use raise risk for IBD in offspring?

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  • Clinical Essentials from Lancet Infect Dis
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Zika: absence in amniocentesis, amniotic fluid inconconclusive

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  • Clinical Essentials from Lancet
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HIV: free self-testing boosts uptake in high-risk population

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  • Conference Essentials
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Opioid abuse: CDC finds increase among black MSM and those of low SES | CROI

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  • Clinical Essentials from MMWR
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Influenza activity in the US thus far: what you need to know

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Professional Essentials

  • US Professional News

More physicians are getting MBAs to cope with health system changes

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  • US Professional News

Physicians continue to offer outdated treatments, article concludes

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  • US Professional News

CMS randomized study of payment program could deter physicians

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  • US Professional News

Should physicians have beards? Gravitas vs hygiene

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  • Patients Will Be Asking

Is testosterone right for me?

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  • Patients Will Be Asking

Could my excessive and circuitous speech be a sign of declining cognition?

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New in Infectious Diseases

  • Clinical Essentials from Hepatology
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DAAs for HCV cirrhosis: MELD score stratifies complication risk

Hepa-C registry data show lowered efficacy, more complications in CTP-B/C.

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  • Clinical Essentials from Euro Surveill
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Influenza vaccine: 2016/17 interim effectiveness in Canada

Continued evolution in circulating 3C.2a variants and their derivatives, and the effect on vaccine effectiveness, warrants ongoing monitoring to inform potential vaccine reformulation.

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Abnormal vaginal microbiota not a bar to effective oral PrEP | CROI
  • Conference Essentials
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Abnormal vaginal microbiota not a bar to effective oral PrEP | CROI

PrEP efficacy did not differ among women with detected versus undetected Gardnerella/Bacteroides and Lactobacillus.

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Global antibiotic stewardship collaboration in five countries
  • The Lancet Infectious Diseases
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Global antibiotic stewardship collaboration in five countries

Antibiotic stewardship is a collaborative, multidisciplinary approach to optimize use of antibiotics

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  • Clinical Essentials from Aliment Pharmacol Ther
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HCV: study supports DAA-related risk for HBV reactivation

Modest flares often occur early and without clinical effect.

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  • Clinical Essentials from Cancer
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Sexual frequency declines after OSCC diagnosis, regardless of HPV status

HPV causes OSCC and is sexually transmitted.

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  • Clinical Essentials from J Acquir Immune Defic Syndr
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HIV: markers of inflammation remain elevated despite early ART initiation

Early ART has been proposed as a strategy to prevent persistent HIV-associated inflammation.

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  • Clinical Essentials from J Hosp Infect
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Infection site, urinary catheter insertion prognostic for severe sepsis

Caution, care bundle approach recommended for bacteremic patients with urinary tract infections.

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  • Clinical Essentials from Medicine (Baltimore)
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Herpes zoster linked to increased risk for Parkinson's disease in seniors

Elevated risk was most marked in the first 3 mo after herpes zoster diagnosis.

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  • Clinical Essentials from PLoS One
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Human endogenous retroviruses further implicated in MS risk

Expression of human endogenous retroviruses was associated with elevated odds of MS.

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  • Clinical Essentials from Gastroenterology
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HCV: 6-trial analysis confirms EBR/GZR efficacy in compensated cirrhosis

An integrated analysis of data from 6 international phase 2/3 trials.

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Point-of-care early infant diagnosis enables earlier and increased ART initiation | CROI
  • Conference Essentials
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Point-of-care early infant diagnosis enables earlier and increased ART initiation | CROI

Novel point-of-care assays may increase access to EID and positively affect clinical care.

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Specific ART regimens used in pregnancy may affect adverse birth outcomes | CROI
  • Conference Essentials
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Specific ART regimens used in pregnancy may affect adverse birth outcomes | CROI

Among infants exposed to ART from conception, TDF/FTC/EFV was associated with the fewest adverse birth outcomes.

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  • Clinical Essentials from Transl Pediatr
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HIV: fetal/neonatal NRTI exposure linked to developmental delay, behavioral disorders

ART is commonly used to reduce maternal HIV transmission.

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