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HCV: 6-trial analysis confirms EBR/GZR efficacy in compensated cirrhosis

An integrated analysis of data from 6 international phase 2/3 trials.

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Skin Cancer Vitals for February 2017

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  • Clinical Essentials from Respir Med
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COPD: aclidinium/formoterol safety, efficacy confirmed at 52 wks

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  • Clinical Essentials from Transl Pediatr
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HIV: fetal/neonatal NRTI exposure linked to developmental delay, behavioral disorders

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Asthma and COPD Vitals for February 2017

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  • Clinical Essentials from U.S. Food and Drug Administration (FDA)
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FDA approves brodalumab for moderate-to-severe plaque psoriasis

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  • Clinical Essentials from Haematologica
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MCL: first-line VR-CAP delivers deep, durable response vs R-CHOP

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  • Clinical Essentials from Clin Ther
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Gefinitib-resistant NSCLC: chemotherapy boosts survival

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  • Clinical Essentials from J Clin Oncol
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Renal cancer: cabozantinib tops sunitinib as first-line treatment

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Professional Essentials

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Bundled payment models delayed, but not in immediate danger, HHS says

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Caribbean medical schools seek better image

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Kennedy says he expects Trump vaccine panel will move forward

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Court strikes down Florida law barring physicians from discussing firearms

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  • Patients Will Be Asking

What would the proposed replacement for Obamacare mean for me?

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Mandatory PDMP use related to safer opioid prescribing

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New in Pharmacy

Specific ART regimens used in pregnancy may affect adverse birth outcomes | CROI
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Specific ART regimens used in pregnancy may affect adverse birth outcomes | CROI

Among infants exposed to ART from conception, TDF/FTC/EFV was associated with the fewest adverse birth outcomes.

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  • Clinical Essentials from Oncotarget
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HCV: HCC risk higher with SVR than spontaneous clearance

Increased risk appears limited to patients with significant fibrosis.

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  • Clinical Essentials from BMC Geriatr
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Patients with dementia less likely to receive opioid analgesics after hip/pelvic fracture

Results of a systematic review.

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Point-of-care early infant diagnosis enables earlier and increased ART initiation | CROI
  • Conference Essentials
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Point-of-care early infant diagnosis enables earlier and increased ART initiation | CROI

Novel point-of-care assays may increase access to EID and positively affect clinical care.

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  • Clinical Essentials from N Engl J Med
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Physician opioid prescribing habits linked to risk for long-term patient use

ER patients treated by the most frequent prescribers are 30% more likely to become long-term users.

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  • Clinical Essentials from Eur J Obstet Gynecol Reprod Biol
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Surgical vs expectant management of incomplete abortion after misoprostol

No differences in fertility, pregnancy complications, or cesarean delivery rates.

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  • Clinical Essentials from BMC Cancer
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DLBCL with SI: which clinical characteristics are linked to better survival?

Findings make a case for consolidation radiotherapy.

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  • Clinical Essentials from Eur J Gastroenterol Hepatol
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HCV: age alone has no impact on DAA efficacy

Veteran's Affairs real-world study examines clearance rates for over 15K patients.

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Dementia Vitals for February 2017
  • Vitals
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Dementia Vitals for February 2017

Albuminuria and dementia | Antidepressants and dementia risk | Managing BPSD.

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  • Clinical Essentials from BMC Neurol
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PegIFN beta-1a for relapsing-remitting MS: 2 years are better than 1

Data from the ADVANCE randomized controlled trial.

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Neonatal HIV: variability seen in virologic response to early ART | CROI
  • Conference Essentials
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Neonatal HIV: variability seen in virologic response to early ART | CROI

Many clinical and social challenges affect engagement in care of this high-risk group of infants.

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  • Clinical Essentials from Hepatology
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Meta-analysis supports risk for HBV reactivation with DAAs

Reactivation occurs earlier and tends to be more severe than with IFN-based therapy.

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  • Clinical Essentials from J Am Geriatr Soc
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Pain is undertreated in US nursing homes

Persistent noncancer pain affects 5% to 49% of nursing home residents.

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  • Clinical Essentials from Diabetes Care
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Study supports use of CGM data for insulin dosing decisions

No differences found between use of CGM alone vs with confirmatory fingerstick glucose measurements.

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