Professional Essentials

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Florida physician gets 4y for fraud

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Italian surgeon claims first head transplant

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Some physicians prescribe homeopathy despite doubts

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Making music from microbes

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AMA seeks simpler e-prescribing

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Physicians favor research from rich countries

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New in Pharmacy

  • Clinical Essentials from Invest New Drugs
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NSCLC: add-on dulanermin boosts PFS in phase 3 trial

Data show synergistic effect with chemotherapy, favorable toxicity profile.

Empagliflozin reduces CV death in adults with T2DM and PAD | AHA
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Empagliflozin reduces CV death in adults with T2DM and PAD | AHA

Added to standard of care, empagliflozin reduced the risk of CV death by 43%.

  • Clinical Essentials from Diabetes Obes Metab
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Intensive diabetes control may increase mortality, depending on medications

Lower HbA1c levels associated with higher mortality in hypoglycemia-prone regimens.

  • Clinical Essentials from Br J Cancer
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HER2+ MBC: trastuzumab retreatment prolongs OS by nearly 2 y

Population-based study of over 3K Australian women.

  • Clinical Essentials from Neuropsychiatr Dis Treat
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Fluvoxamine effective for depression with neurological disorders

The drug may also improve sleep and cognitive function, but those findings need to be confirmed in clinical studies.

Diabetes Vitals for November 2017
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Diabetes Vitals for November 2017

Suboptimal diabetes screening for the severely mentally ill | Antidepressants linked to pediatric T2DM risk | Language guidelines for diabetes encounters | Diabetes specialists underestimate NAFLD burden.

  • Clinical Essentials from Stroke
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SSRIs not linked to post-thrombolysis intracerebral hemorrhage

An analysis of registry data for more than 6000 patients.

  • Clinical Essentials from Int J Cancer
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Dietary isoflavones tied to increased risk for advanced prostate cancer

PLCO data show 91% increased risk in highest vs lowest quintile of intake.

  • Clinical Essentials from Gastroenterology
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Gastric and esophageal cancer: no survival benefit for aspirin

A study of cancer registries in England and Scotland.

Canagliflozin reduces CV events in patients with T2DM and prior CV events | AHA
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Canagliflozin reduces CV events in patients with T2DM and prior CV events | AHA

Primary endpoint was composite of CV death, nonfatal myocardial infarction, or nonfatal stroke.

  • Clinical Essentials from Lancet Oncol
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NSCLC: first-line pembrolizumab tops chemotherapy for quality of life

Prior studies demonstrated superior PFS and OS vs chemotherapy.

  • Clinical Essentials from Lancet Oncol
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Neratinib for breast cancer: 5-y data from the phase 3 ExteNET trial

FDA approval was based on 2-y data.

  • Clinical Essentials from J Clin Psychiatry
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Valbenazine has a lasting effect on tardive dyskinesia

Valbenazine (Ingrezza) has a favorable safety, toxicity profile with no apparent akathisia/parkinsonism worsening.

Primary Care Oncology Vitals for November 2017
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Primary Care Oncology Vitals for November 2017

The highest-sensitivity FOBT | Bisphosphonates reduce bone mets risk in early breast cancer | Weight-related cancers on the rise.