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AACR 2022 — A novel natural killer cell-based immunotherapy for CD30+ relapsed/refractory lymphomas

Elena Riboldi — Agenzia Zoe | Conference Report | 14 April 2022

Preactivated allogeneic NK cells combined with a first-in-class bispecific antibody show very encouraging activity in heavily pretreated patients.

Takeaway

In patients with CD30+ relapsed/refractory lymphomas, infusions of preactivated cord blood (CB)-derived natural killer (NK) cells complexed with AFM13, a bispecific antibody that binds CD16A on NK cells and CD30 on lymphoma cells, are safe.
The approach showed early efficacy and warrants further investigation.

Why this matters

CB-derived NK...

General Medicine

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