- Specialists in allergy and immunology show low rates of screening for alpha-1 antitrypsin deficiency (AATD) in symptomatic patients and miss opportunities for early diagnosis.
Why this matters
- AATD is underdiagnosed, with many patients experiencing years of symptoms and seeing numerous healthcare providers before appropriate diagnosis.
- First symptom is often dyspnea on exercise and can mimic asthma.
- The American Thoracic Society/European Respiratory Society recommend AATD screening in all patients with COPD, patients with unexplained liver disease or bronchiectasis, and patients with asthma with fixed obstructive disease.
- Allergist/immunologists should increase screening for AATD, particularly in patients with asthma who have fixed obstructive disease.
- Information on patient diagnosis and treatment patterns was collected from 500 patients with severe AATD ...