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ACC 2022 — 'Gene silencing' therapy shows early promise in Lp(a) reduction

Pavankumar Kamat   |   Conference Report   |   07 April 2022
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Takeaway

  • A single subcutaneous injection of a short interfering RNA (siRNA), SLN360, was well tolerated and resulted in significant reductions in plasma lipoprotein(a) (Lp[a]) levels in a small phase 1 trial.

Why this matters

  • Lp(a) is a key risk factor for atherothrombotic cardiovascular disease (CVD) and aortic stenosis, which has...

          

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