Anti-citrullinated peptide antibodies a bad sign for RA patients in remission

Access to the full content of this site is available only to registered healthcare professionals. Register to read more


  • Anti-citrullinated peptide antibodies (ACPA) predict clinically relevant radiographic progression (CRRP) at 1 y in patients with rheumatoid arthritis (RA) with low disease activity (LDA) at baseline.

Why this matters

  • This group previously reported on CRRP prognostic markers in moderate- to high-disease activity patients with RA.
  • CRRP can occur despite clinical remission or LDA, perhaps because of residual synovitis.

Key results

  • 3 strong prognostic factors for CRRP at 1 y were found. They were:
  • ACPA positivity (OR, 15.2; P=.0007).
  • Time-integrated disease activity score in 28 joints-erythrocyte sedimentation rate during 1 y (7.85-unit increase; OR, 1.83; P=.036).
  • Baseline modified total Sharp score on radiographs (13-unit increase; OR, 1.22; P=.0073).
  • 35% of ACPA-positive patients relapsed during 1 y vs 19% of ACPA-negative patients (P=.011).

Study design

  • Post...