Are genetic tests worthwhile in predicting diabetes or its complications?
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- At this time, genetic tests are not useful as predictors of onset of diabetes or its complications.
- Patients should be warned about the poor sensitivity of currently marketed diabetes risk tests and instead encouraged to enroll in clinical trials to better inform the field.
Why this matters
- Genetic risk tests are being marketed to clinicians and patients.
- Review of evidence for the ability of genetic tests to discriminate between people who will or who will not develop diabetes or its complications.
- Funding: Italian Ministry of Health.
- Genetic prediction of type 1 diabetes is feasible in families via diabetes-specific autoantibodies, but because there is currently no prevention approach, clinical usefulness is questionable....