Diabetes/Endocrinology

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HIV/Infectious Diseases

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ASCO 2022 – The ‘HER2-low revolution’ in breast cancer treatment

Cristina Ferrario — Agenzia Zoe | Conference Report | 07 June 2022

First phase 3 trial shows benefits of a HER2-directed therapy (trastuzumab deruxtecan) in this new subgroup and changes standard-of-care

Takeaway

In patients with HER2-low unresectable and/or metastatic breast cancer (mBC), the HER2-targeting antibody-drug conjugate trastuzumab deruxtecan (T-DXd) improved progression-free survival (PFS) and overall survival (OS) compared to chemotherapy (49% reduction in risk of progression, and 36% reduction in risk of death).
No new safety concerns were identified.
HER2-low mBC...

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