ASHG: At 58%, the heritability of prostate cancer is highest of any malignancy

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According to data from the Nordic Twin Registry of Cancer (NorTwinCan) presented at ASHG, held in October in Boston, the heritability of prostate cancer is 58%, the highest of any malignancy.

NorTwinCan includes 133,689 monozygotic (MZ) and dizygotic (DZ) twin pairs (N=267,378) from nationwide registries in Denmark, Finland, Norway, and Sweden. In this latest update, Scandinavian and American investigators incorporated novel time-to-event analyses to estimate the concordance risk and heritability for 23 unique malignancies, with follow-up from cancer registration and accounting for censoring and competing risks of death through 2009.

During a median 40 year follow-up, 29,599 cancer cases were diagnosed. The heritability for prostate cancer was 58%, the highest of any malignancy. The ...