Asymptomatic pyuria: a risk factor for adverse pregnancy outcomes

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Takeaway

  • Asymptomatic pyuria during pregnancy is associated with adverse birth outcomes.

Why this matters

  • Asymptomatic bacteriuria affects 4% to 40% of pregnant women.
  • Routine urine culture in pregnant women during the first trimester is recommended.
  • It has been postulated that the mechanism of urinary tract infections and preterm birth are related to the production phospholipase A2 by microorganisms that activates prostaglandins.
  • Urine analysis is less expensive than urine culture and can quickly detect pyuria.

Key results

  • Pyuria was associated with increased risk for preterm delivery (<36 wk, OR, 2.231; P=.009).
  • Pyuria was associated with increased risk for preterm premature rupture of membranes (PPROM, OR, 4.269; P=.003).
  • Pyuria was associated with low birth weight (OR, 1.758; P=.035).
  • Pyuria was associated with low Apg...