Brain volume and white matter in youth with type 2 diabetes

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Takeaway
  • Results from a current pilot study illuminate a host of brain morphology differences between youth with T2DM, obese youth, and normal-weight controls
Methods
  • 15 adolescents underwent Magnetic Resonance Imaging (MRI) for the collection of gray matter volume and white matter integrity (12-21-years-old, 80% Caucasian, 15% African American, mean BMI=32), comprising:
- 5 with T2DM confirmed by oral glucose tolerance test
- 5 matched obese adolescent controls without diabetes (OBCN)
- 5 matched (race, sex) normal-weight controls (NWCN)

Results
  • The normal-weight group had significantly greater volume than the obese and T2DM groups (NWCNOBCN, p=0.020; OBCNT2DM, p=0.042; and NWCNT2DM; p=0.003) after controllin...