Breast cancer: factors associated with accuracy of intraoperative SLN evaluation
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Primary tumor histology and metastasis size are associated with the accuracy of intraoperative sentinel lymph node (SLN) evaluation in patients with breast cancer.
Why this matters
Identification of accuracy associated factors should aid intraoperative decision-making.
Favorable histology (OR, 3.32; P=.005), invasive lobular histology (OR, 4.8; P=.001), absence of lymphovascular invasion (LVI, OR, 0.37; P=.006), and micrometastasis (OR, 8.44; P<.0001) were associated with a higher false-negative (FN) rate in univariate analysis, while neoadjuvant therapy was not (OR, 1.82; P=.07).
Favorable histology (OR, 4.39; P=.02), invasive lobular histology (OR, 6.15; P=.006), and micrometastasis (OR, 7.29; P<.0001) were independently associated with the FN rate in multivariate analysis.
LVI (OR, 0.59; P.05) and neoadjuvant therapy (OR, 0.67; P.05) were not significantly associated with FN rate in multivariate analysis.