Breast cancer: factors associated with accuracy of intraoperative SLN evaluation

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  • Primary tumor histology and metastasis size are associated with the accuracy of intraoperative sentinel lymph node (SLN) evaluation in patients with breast cancer.

Why this matters

  • Identification of accuracy associated factors should aid intraoperative decision-making.

Key results

  • Favorable histology (OR, 3.32; P=.005), invasive lobular histology (OR, 4.8; P=.001), absence of lymphovascular invasion (LVI, OR, 0.37; P=.006), and micrometastasis (OR, 8.44; P<.0001) were associated with a higher false-negative (FN) rate in univariate analysis, while neoadjuvant therapy was not (OR, 1.82; P=.07).
  • Favorable histology (OR, 4.39; P=.02), invasive lobular histology (OR, 6.15; P=.006), and micrometastasis (OR, 7.29; P<.0001) were independently associated with the FN rate in multivariate analysis.
  • LVI (OR, 0.59; P.05) and neoadjuvant therapy (OR, 0.67; P.05) were not significantly associated with FN rate in multivariate analysis.

Study design

  • 681 patien...