C-section delivery: ketamine/propofol is safe, effective for post-op pain

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  • Ketofol (a combination of ketamine [Ketalar] and propofol [Diprivan]) is more effective and safer than 3 other controls used to relieve pain of Caesarean section (C-section), according to a double-blind randomized controlled trial.
Why this matters
  • The global rate of C-sections is 32.0% and rising.
  • Post-op pain causes distress and interferes with infant bonding and breast-feeding.
Study design
  • This was a double-blind randomized controlled trial of 92 women undergoing C-section under spinal anesthesia.
  • The patients were randomly assigned, immediately after clamping the umbilical cord, to intravenous ketamine (.25 mg/kg), propofol (.25 mg/kg), ketofol (25 mg ketamine plus 25 mg propofol) or placebo (saline).
  • Funding: Ilam University of...