Carbapenem-resistant enterobacteriacae: widespread regional endemicity

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  • Data from healthcare facilities in Washington, DC, demonstrate carbapenem-resistant Enterobacteriaceae (CRE) endemicity within and across healthcare facilities in the District of Columbia.
  • More widespread than previously believed, with great potential for community and hospital colonization, CRE infections represent a significant clinical and public health concern requiring the establishment of baseline regional rates and ongoing surveillance.

Why this matters

  • CRE infections have limited or no treatment options, and invasive CRE infections are associated with mortality rates ≤50%.
  • Data demonstrating the likelihood of CRE transmission within clustered regional healthcare facilities highlight the need for multidisciplinary clinical awareness of transmission risks, coordinated diagnosis, and prevention.

Key results

  • Overall, 53 samples tested positive for CRE, with a prevalence of 5.2% (95% CI, 3.9%-6.8%).
  • Depending on the facility type and un...