Cervical cancer: EGFR overexpression linked to decreased survival

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Takeaway
  • EGFR overexpression might be a predictive biomarker of reduced survival in patients with cervical cancer; these findings could help facilitate treatment decisions.
Study design
  • Meta-analysis that included 22 studies with 2505 patients that investigated the association between EGFR expression and survival in cervical cancer.
  • Funded by the Guangdong Province Medical Science Technology and the Guangdong Pharmaceutical Association Fund.
Key results
  • High EGFR levels predicted poor OS (HR, 1.40; 95% CI, 1.10-1.78), as well as DFS (HR, 1.84; 95% CI, 1.51-2.24).
  • EGFR overexpression was significantly related to poor DFS among patients who received chemoradiation or surgery.
  • Pooled ORs showed associations between EGFR expression and several clinicopathologica...