Cervical cancer: VTE linked to decreased survival

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  • The occurrence of venous thromboembolism (VTE) is associated with poorer survival outcomes in women with cervical cancer.
Study design
  • Retrospective study that included 798 patients with stage I-IV cervical cancer cases diagnosed between 2000 and 2014 at a single academic institution.
  • Risk factors for VTE were examined, as well as the effect of VTE on survival outcomes.
  • Funding: No funding source disclosed.
Key results
  • VTE was recorded in 98 (12.3%) patients.
  • Albumin level at diagnosis, stage, and receipt of systemic chemotherapy were independent risk factors associated with development of VTE on multivariable analysis.
  • The risk of developing VTE during and within 1 mo after chemotherapy was significantly higher in patients receiving cisplatin and gemcitabine (11/42 cases, 26.2%) vs other regimens (0/38 cases; P<.001).
  • On multivariable analysis, VTE remained an independent prognostic factor as...