Cesarean delivery: meperidine tops APAP for post-op pain

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  • The weak opioid meperidine (Demerol) provides greater pain relief after cesarean delivery than paracetamol (Tylenol; acetaminophen [APAP]), but with more vomiting as an adverse effect.
Why this matters
  • Better pain control after cesarean delivery ameliorates maternal distress and enhances stronger bonding with offspring.
Study design
  • In this double-blind study, 70 women undergoing cesarean delivery were randomly assigned to paracetamol (n=35; dose 1 g in 100 mL saline) or meperidine (n=35; dose 25 mg in 100 mL saline).
  • Outcome measures were pain (by visual analog scale) and vomiting in the recovery room and surgical ward.
  • Funding: No external funding.
Key results
  • Pain scores were no different in the recovery room (30 min after...