Childhood ALL treatment associated with risk of dental defects in later life

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  • A study of Norwegian survivors of childhood acute lymphoblastic leukemia (ALL) found age at cancer diagnosis and dose of anthracyclines to be strongly associated with severity of dental defects

Key Results

  • 29.1 years mean age at examination
  • 22.9 years mean follow-up period
  • Diagnosis occurring at ≤5 years of age (B = -9.6, P<.001) and a cumulative dose of anthracyclines >120 mg/m2 (B = 11.5, P<.001) were strongly associated with more severe dental defects
  • More caries was seen in patients treated after the age of 5 vs those treated at younger ages (P=.001)

Study Design

  • Study population: 111 Norwegian survivors of ALL diagnosed before the age of 16
  • All patients completed a questionnaire and underwent medical and oral examination
  • Dental defects were registered...