CML-CP: augmenting Sokal risk scores with bone marrow parameters

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  • In patients with chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib (Gleevec), the incorporation of bone marrow (BM) parameters into Sokal risk scores improved prognostic capability for PFS in low- and intermediate-risk groups.
  • BM parameters did not improve prognostic capability for OS in low- and intermediate-risk groups.

Why this matters

  • Risk scoring systems such as Sokal and European Treatment and Outcome Study (EUTOS) currently incorporate peripheral blood (PB) parameters.

Study design

  • Study to investigate whether Sokal and EUTOS risk score capabilities can be improved through the incorporation of BM parameters in 371 patients ...