Coffee, decaf or not, is linked to reduced HCC risk

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  • A couple of extra cups of coffee a day, decaffeinated or regular, may reduce risk for hepatocellular carcinoma (HCC), even in people who already have liver disease, according to this large meta-analysis.

Why this matters  

  • Some previous studies have suggested a protective effect of coffee in HCC, although no randomized controlled trials have addressed the question.

Key results 

  • With 2 extra cups of coffee daily, HCC relative risk (RR) was 0.65.
  • Case-control studies (RR, 0.53) found stronger link vs cohort studies (RR, 0.71), but the latter were generally lower quality. 
  • Liver disease or disease stage, BMI, high alcohol consumption, diabetes,...