Colon cancer: does left vs right-sided location play a prognostic role?
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Left-sided colon cancer (CC) tumors are associated with a 20% reduced risk for death.
Results from this large meta-analysis indicate that CC side should be used as a criterion for establishing prognosis in all stages of disease and should be considered when deciding treatment intensity for metastatic disease.
Why this matters
Primary tumor location has emerged as an important prognostic factor based on biological differences, but its role in deciding treatment is less clear.
Total of 6 studies involving 1,437,846 patients were included in the analysis, with a median follow-up of 65 mo.
Compared with right-sided tumors, left-sided primary tumor location was asso...