Colon cancer: does left vs right-sided location play a prognostic role?

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  • Left-sided colon cancer (CC) tumors are associated with a 20% reduced risk for death.
  • Results from this large meta-analysis indicate that CC side should be used as a criterion for establishing prognosis in all stages of disease and should be considered when deciding treatment intensity for metastatic disease.

Why this matters

  • Primary tumor location has emerged as an important prognostic factor based on biological differences, but its role in deciding treatment is less clear.

Key results

  • Total of 6 studies involving 1,437,846 patients were included in the analysis, with a median follow-up of 65 mo.
  • Compared with right-sided tumors, left-sided primary tumor location was asso...