Combination BRAF and MEK inhibition provides HRQoL advantage vs BRAF inhibitor monotherapy

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Takeaway
  • A study of health-related quality of life scores from a phase III study in BRAF Val600 mutation-positive metastatic melanoma found combination dabrafenib + trametinib to provide benefits over vemurafenib monotherapy 
Study Design
  • Pre-specified prospective analysis of HRQoL from a Phase III, open-label, randomised study (COMBI-v) of patients with BRAF Val600 mutation-positive metastatic melanoma
  • Study population: 704 patients
  • Treatment: 352 patients were randomized to receive dabrafenib (150 mg twice-daily) and trametinib (2 mg once-daily); 352 patients were randomized to receive vemurafenib monotherapy (960 mg twice-daily) orally as first-line therapy
  • Key measurements: HRQoL in the intention-to-treat population with the European Organisation for Research and Treatment of Cancer quality of life (EORTC QLQ-C30), EuroQoL-5D (EQ-5D), and Melanoma Subscale of the Functional Assessment of Cancer Therapy-Melanoma (FACT-M)
Key Results
  • High rate of questionnaire completion: 95% at baseline, 80% at follow-up ...