Community-acquired pneumonia ups risk of future heart failure, especially in young adults

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  • Substantially increased short- and long-term risk for incident heart failure after in- or outpatient pneumonia across all adult age-groups.

Why this matters

  • Postdischarge cardiovascular prevention might be warranted, including awareness that subsequent dyspnea might be new-onset heart failure.

Study design

  • Prospective, population-based study.
  • Adults with community acquired pneumonia admitted to any of 6 hospitals or 7 emergency departments in Edmonton, Canada.
  • Up to 5 frequency matched control patients per patient.
  • Primary outcome was subsequent heart failure-related hospitalization.
  • Funding: None.

Key results

  • 4988 patients and 23,060 control patients.
  • Median follow-up was 9.9 y.
  • Patients had higher rate of incident heart failure than control patients (P<.001), including within 90 d of index event (P=.015), at 1 y (P<.001), and combined endpoint of incident heart failure or all cause mortality (P<.001).
  • 10-y heart failure risk after pneumonia was approximately 12%.
  • ...