Congenital Zika syndrome linked to severe ocular abnormalities

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  • Venezuelan, Columbian case data demonstrate that congenital Zika (ZIKV) syndrome (CSZ; a constellation of consistent, unique anomalies associated with intrauterine ZIKV infections) is associated with severe, bilateral, ocular abnormalities.
  • These findings make it imperative that all infants with microcephaly-associated, clinically diagnosed ZIKV undergo ophthalmic evaluation.

Why this matters

  • Recognition of manifestations of CZS helps guide differential diagnosis and timely evaluation/follow-up of affected infants.
  • CZS-associated ocular anomalies include focal pigment modeling with a predilection for macular area, optic disc hypoplasia, lacunar maculopathy, chorioretinal scars, and for the first time, congenital glaucoma.
  • Routine ophthalmic examination focusing on abnormal ocular changes recommended for all exposed infants.

Study design

  • Prospective case series examining ocular manifestations of congenital Zika syndrome in infants with microcephaly (n=43) ...