Congenital Zika syndrome linked to severe ocular abnormalities
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Venezuelan, Columbian case data demonstrate that congenital Zika (ZIKV) syndrome (CSZ; a constellation of consistent, unique anomalies associated with intrauterine ZIKV infections) is associated with severe, bilateral, ocular abnormalities.
These findings make it imperative that all infants with microcephaly-associated, clinically diagnosed ZIKV undergo ophthalmic evaluation.
Why this matters
Recognition of manifestations of CZS helps guide differential diagnosis and timely evaluation/follow-up of affected infants.
CZS-associated ocular anomalies include focal pigment modeling with a predilection for macular area, optic disc hypoplasia, lacunar maculopathy, chorioretinal scars, and for the first time, congenital glaucoma.
Routine ophthalmic examination focusing on abnormal ocular changes recommended for all exposed infants.
Prospective case series examining ocular manifestations of congenital Zika syndrome in infants with microcephaly (n=43) ...