CRE prevalence rising in community-acquired infections
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Data suggest an increasing prevalence of carbapenem-resistant Enterobacteriaceae (CRE) among patients hospitalized for serious infections in the United States; since 2013, Centers for Disease Control and Prevention surveillance has increased.
A substantial proportion of CRE appears to be community-acquired, warranting increased efforts to identify infections and optimize empiric therapy in hospitalized patients.
Why this matters
Empiric therapy delays and selecting treatment to which the infecting pathogen is nonsusceptible may increase mortality risk 2- to 5-fold, highlighting the need for clinician education about shifting antimicrobial susceptibility patterns.
CRE is increasing in community-onset urinary tract infections, pneumonia, and sepsis, and is associated with 4-fold higher risk for inappropriate empiric treatment (IET) and poor outcomes/mortality.
CRE prevalence vs carbapenem-susceptible Enterobacteriaceae (CSE)...