CRE prevalence rising in community-acquired infections

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  • Data suggest an increasing prevalence of carbapenem-resistant Enterobacteriaceae (CRE) among patients hospitalized for serious infections in the United States; since 2013, Centers for Disease Control and Prevention surveillance has increased.
  • A substantial proportion of CRE appears to be community-acquired, warranting increased efforts to identify infections and optimize empiric therapy in hospitalized patients.

Why this matters

  • Empiric therapy delays and selecting treatment to which the infecting pathogen is nonsusceptible may increase mortality risk 2- to 5-fold, highlighting the need for clinician education about shifting antimicrobial susceptibility patterns.
  • CRE is increasing in community-onset urinary tract infections, pneumonia, and sepsis, and is associated with 4-fold higher risk for inappropriate empiric treatment (IET) and poor outcomes/mortality.

Key results

  • CRE prevalence vs carbapenem-susceptible Enterobacteriaceae (CSE)...