Dabrafenib plus trametinib: potential new therapy for BRAF-mutant NSCLC

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  • Takeaway

    • Dabrafenib combined with trametinib could be a new treatment for patients with BRAFV600E-mutant NSCLC.

    Study design

    • Phase 2 multicenter, international and non-randomized trial that enrolled 59 patients with pretreated metastatic stage IV BRAFV600E -mutant NSCLC who had progressed after standard treatment.
    • Patients received oral dabrafenib (150 mg twice daily) plus oral trametinib (2 mg once daily) in continuous 21-d cycles until disease progression, intolerable toxicity, withdrawal of consent, or death.
    • The study is ongoing.

    Key results

    • At 11.6 mo follow-up (interquartile range, 8.8–15.2), 36 (63.2% [95% CI, 49.3–75.6]) patients achieved overall response: 2 (4%) with complete responses and 34 (60%) with partial responses.
    • 45 patients (78.9% [95% CI, 66.1–88.6) achieved disease control (complete response + partial response + stable disease).
    • Median progression-free survival was 9.7 mo (95% CI, 6.9–19.6); 32 patients had disease progression or died by ...