DAPT+VKA combo linked to lower stroke risk, mortality in Afib after PCI with stent
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Dual antiplatelet therapy (DAPT)+vitamin K antagonist is linked with lower stroke, stent thrombosis, all-cause mortality in atrial fibrillation (Afib) after percutaneous coronary intervention (PCI) vs DAPT alone but higher major bleeding risk.
Why this matters
Controversy remains regarding outcomes with triple therapy vs DAPT alone following stent implantation in patients with Afib undergoing PCI.
Higher major bleeding risk with triple therapy (OR, 0.62; P<.0001).
No differences for myocardial infarction, major adverse cardiovascular event (ORs, 1.27 and 1.17, respectively).
Stent thrombosis, stroke, all-cause mortality lower with triple therapy vs DAPT (ORs,...