Dasatinib for elderly CML: can reducing dose increase viable patients?

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  • Dasatinib (Sprycel) was well tolerated and delivered molecular response to most patients aged ≥65 y with chronic myeloid leukemia (CML) at the low dose of ≤20 mg/d.

Why this matters

  • Dasatinib is significantly more potent than imatinib in terms of in vitro BCR-ABL inhibition.
  • Older patients may not be viable candidates for tyrosine kinase inhibitor (TKI) therapy due to increased risk for grade 3-4 hematologic and nonhematologic toxicities and presence of comorbidities.

Study design

  • Analysis to investigate the safety and efficacy of low-dose dasatinib in 21 elderly patients with CML in chronic phase (CML-CP); 77% had newly diagnosed CML.
  • Initial dose was determined on an individual basis.
  • Funding: No...