- After 6 wk, magnesium supplementation was associated with reduced symptoms of depression and anxiety, but the study did not include a placebo control.
Why this matters
- Magnesium supplementation is safe and inexpensive.
- 108 adults with depression were randomly assigned to 6 wk of treatment (248 mg of elemental magnesium per day) or to delayed treatment.
- Funding: University of Vermont.
- After adjustment for confounders, there was a clinically significantly higher net improvement in Patient Health Questionnaire-9 score during treatment periods than during nontreatment periods (difference, −6.0 points; P<.001).
- Similarly, magnesium supplementation was associated with greater improvement in anxiety symptoms (Generalized Anxiety Disorders-7 scale difference, −4.5 points; P<.001).
- 61% of participants said they planned to take magnesium supplements in the future.
- The study was not placebo controlled or blinded.