Does the AJC cancer staging system predict prognosis in patients with locally advanced esophageal squamous cell carcinoma?

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  • Postchemoradiotherapy (post-CRT) pathologic stage classified according to American Joint Committee on Cancer, 7th edition staging (AJCC-7) predicted survival in locally advanced esophageal squamous cell carcinoma (ESCC) patients treated with preoperative paclitaxel and cisplatin-based CRT followed by esophagectomy.

Study design

  • This study evaluated the prognostic value of AJCC-7 staging in 140 patients from three phase II trials of preoperative CRT (twice weekly paclitaxel and cisplatin-based regimens and 40-Gy radiotherapy in 20 fractions) for locally advanced ESCC; median follow-up was 61.9 months.

Key results

  • For the entire cohort, median progression-free survival (PFS) and overall survival (OS) were 24.5 and 30.9 months, respectively.
  • Post-CRT pathologi...