Further evidence for role of Ki-67 as a prognostic marker in early-stage non-small cell lung cancer

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  • Elevated Ki-67 expression was associated with a poorer outcome in non-small cell lung cancer (NSCLC) patients, particularly in early-stage Asian adenocarcinoma (ADC) patients, though studies with larger numbers of patients are needed to validate these findings.

Study design

  • This meta-analysis analyses the associations between Ki-67 expression and clinical outcome in 5600 NSCLC patients from 32 studies.

Key results

  • Results suggested that high Ki-67 expression was negatively associated with overall survival (OS; HR = 1.59, 95 % CI 1.35-1.88, P < 0.001) and disease-free survival (DFS; HR = 2.21, 95 % CI 1.43-3.42, P < 0.001) in NSCLC patients.
  • Subgroup analysis suggeste...