GLUT-1 overexpression: a negative prognostic indicator in CRC
Access to the full content of this site is available only to registered healthcare professionals.
Register to read more
This meta-analysis found that overexpression of glucose transporter-1 (GLUT-1) is associated with worse DFS in rectal cancer, and correlated with aggressive clinical features in colorectal cancer (CRC).
Why this matters
GLUT-1 is overexpressed in various malignancies, but its precise prognostic value in CRC remains unclear.
Meta-analysis included 14 studies involving 2077 patients.
In CRC, GLUT-1 was not significantly associated with OS (HR=1.28; P=.22) or DFS (HR=1.71; P=.179).
Subgroup analysis in rectal cancer found that GLUT-1 was a significant biomarker for poor DFS (HR=2.47; P=.013).
GLUT-1 expression was significantly correlated with various clinical features in CRC: presence of lymph node metastasis (n=...