HCC: lower recurrence with liver transplantation than partial hepatectomy
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Liver transplantation (LT) is associated with lower recurrence rates than partial hepatectomy in patients with hepatocellular carcinoma (HCC).
Why this matters
Understanding specific outcomes of LT is important due to the shortage of liver donors.
LT patients had better 5-y DFS than non-LT patients (79% vs 35%; P<.001).
In subgroup analysis, the association between LT and 5-y DFS was specific to American Joint Committee on Cancer (AJCC) stage I-II patients (84% vs 40%; P<.001) and not significant in AJCC stage III-IV patients (23% vs 15%; P=.295).
LT (HR, 0.321; P<.001), preoperative α-fetoprotein (HR, 1.305; P=.012), angioinvasion (HR, 1.391; P=.004), tumor multiplicity (HR, 1.44; P=.001), tumor extent (HR, 1.61; P<.001), tumor size (HR, 1.291; P=.026), and Edmonson-Steiner nuclear grade (HR, 1.265; P=.034) were associated with DFS of stage I-II patients in multivariate analysis.
858 patients with HCC, 338 who underwent LT and 520 who underwent partial hepatectomy, were analyzed for DFS and associated factors.
Funding: Korea Health Industry Development Institute.