HCC: lower recurrence with liver transplantation than partial hepatectomy

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Takeaway

  • Liver transplantation (LT) is associated with lower recurrence rates than partial hepatectomy in patients with hepatocellular carcinoma (HCC).

Why this matters

  • Understanding specific outcomes of LT is important due to the shortage of liver donors.

Key results

  • LT patients had better 5-y DFS than non-LT patients (79% vs 35%; P<.001).
  • In subgroup analysis, the association between LT and 5-y DFS was specific to American Joint Committee on Cancer (AJCC) stage I-II patients (84% vs 40%; P<.001) and not significant in AJCC stage III-IV patients (23% vs 15%; P=.295).
  • LT (HR, 0.321; P<.001), preoperative α-fetoprotein (HR, 1.305; P=.012), angioinvasion (HR, 1.391; P=.004), tumor multiplicity (HR, 1.44; P=.001), tumor extent (HR, 1.61; P<.001), tumor size (HR, 1.291; P=.026), and Edmonson-Steiner nuclear grade (HR, 1.265; P=.034) were associated with DFS of stage I-II patients in multivariate analysis.

Study design

  • 858 patients with HCC, 338 who underwent LT and 520 who underwent partial hepatectomy, were analyzed for DFS and associated factors.
  • Funding: Korea Health Industry Development Institute.

Limitations

  • H...