HCC: microRNA linked to progression and poor survival
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Expression of microRNA (miR)-106b is associated with reduced survival of patients with hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC).
120 patients with HCC who underwent resection were analyzed by quantitative real-time reverse-transcription PCR for miRNAs associated with HCC incidence, pathology, and prognosis.
miR-106b expression is significantly higher in patients with HCC (P<.01), with expression significantly higher in patients with HBV-associated HCC compared with patients with hepatitis C virus (HCV)-associated HCC (P<.05) and non-HBV/non-HCV-associated HCC (P<.001).
miR-106b expression was significantly associated with HCC differentiation (well vs moderate, P=.0359; well vs poor, P=.0145).
High miR-106b expression was significantly associated with reduced 5-y overall survival (65% vs 93%, ...