HCC: microRNA linked to progression and poor survival

Access to the full content of this site is available only to registered healthcare professionals. Register to read more

Takeaway

  • Expression of microRNA (miR)-106b is associated with reduced survival of patients with hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC).

Study design

  • 120 patients with HCC who underwent resection were analyzed by quantitative real-time reverse-transcription PCR for miRNAs associated with HCC incidence, pathology, and prognosis.

Key results

  • miR-106b expression is significantly higher in patients with HCC (P<.01), with expression significantly higher in patients with HBV-associated HCC compared with patients with hepatitis C virus (HCV)-associated HCC (P<.05) and non-HBV/non-HCV-associated HCC (P<.001).
  • miR-106b expression was significantly associated with HCC differentiation (well vs moderate, P=.0359; well vs poor, P=.0145).
  • High miR-106b expression was significantly associated with reduced 5-y overall survival (65% vs 93%, ...