HER2+ advanced breast cancer: primary results from the phase 3 MARIANNE study

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  • In human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer, trastuzumab emtansine (T-DM1; Kadcycla) with or without pertuzumab (Perjeta) was noninferior in efficacy, but more tolerable than taxane plus trastuzumab (Herceptin).
Why this matters
  • T-DM1 with or without ...