High-dose spironolactone doesn’t improve on usual care for acute HF

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Takeaway 

  • The addition of spironolactone (Aldactone) to usual care for 96 h in patients with acute heart failure (HF) does not improve any endpoints vs outcomes with usual care.
  • Blood and urine biomarkers, weight, symptoms, and congestion levels were similar between the groups.

Why thi...