High transforming growth factor B type 2 expression is linked to poorer survival in breast cancer | PLoS One

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  • High expression of Transforming growth factor beta type II (TβRII) is associated with lymph node metastasis, increasing tumor clinical stage and poorer 5-year disease-free survival (DFS) in breast cancer.

Key Results
  • Of 108 breast cancer patients, 60 were TβRII positive and 48 were TβRII negative.
  • TβRII expression was increased in patients with lymph node metastasis compared to those without lymph node metastasis (67.4% bs. 46.8%, P=.033).
  • A significant association was found between increasing tumor clinical stage and high TβRII expression (P=.011).
  • TβRII expression was not linked to expression of estrogen receptor, progesterone receptor, and HER2.
  • High TβRII expression was associated with ...