HNC: pre-CRT lymphocyte-to-monocyte ratio predicts survival

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  • The pretreatment lymphocyte-to-monocyte ratio (LMR) is an independent prognostic factor for patients with head and neck cancer (HNC) undergoing chemoradiotherapy (CRT).

Key results

  • A high LMR was associated with laryngeal cancer (P=.049), T1-T2 stage disease (P=.038), and clinical stage I-II disease (P=.046).
  • A high neutrophil-to-lymphocyte ratio (NLR) was associated with oropharyngeal/hypopharyngeal cancer (P=.004), T3-T4 stage disease (P=.005), N2b-N3 stage disease (P<.001), and clinical stage III-IV disease (P=.003).
  • High NLR, high platelet-to-lymphocyte ratio (PLR), and low LMR were associated with reduced OS (P<.0001, P=.001, and P<.0001, respectively) and DFS (P<.0001, P=.006, and P<.0001, respectively).
  • LMR was independently associated with prognosis in multivariate analysis (HR, 0.439; 95% CI, 0.282-0.685; P<.001).

Study design

  • 285 patients with HNC treated with CRT were analyze...