How long should DAPT continue after drug-eluting stent implantation?

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Takeaway

  • Compared with 12-mo dual antiplatelet therapy (DAPT), 6-mo DAPT did not increase the composite events of cardiac death, myocardial infarction, stroke, or Thrombolysis in Myocardial Infarction (TIMI) major bleeding at 1 y in patients who underwent long-length everolimus-eluting stent implantation.

Study design

  • Prospective, randomized, multicenter study.
  • 1400 patients (mean total length of implanted stent 45 mm) were randomly assigned to receive 6-mo (n=699) or 12-mo (n=701) DAPT.
  • Primary endpoint: composite of cardiac death, myocardial infarction, stroke, or TIMI major bleeding at 1 y.

Key results

  • Primary endpoint occurred in 15 patients (2.2%) in the 6-mo DAPT group and 14 patients (2.1%) in the 12-mo DAPT group (HR, 1.07; P=.854).
  • Definite or probable stent thrombosis occurred in 2 patients (0.3%) in the 6-mo DAPT group and in 2 patients (0.3%) in the...