HPV-positive OPSCC: E6 expression predicts metastasis and death

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  • High expression of the E6 gene is associated with distant metastasis and poor survival of patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC).

Study design

  • An initial cohort of 39 patients with HPV-positive OPSCC and a validation cohort of 93 patients with HPV-positive OPSCC were analyzed for associations between E6 expression and clinical outcomes.

Key results

  • High E6 expression was significantly associated with distant metastasis in the initial cohort of 39 HPV-positive OPSCC specimens (P=.029).
  • In the validation cohort, patients with high E6 expression had significantly higher rates of distant metastasis (26% ...