Implementing SPRINT targets can save more than 100,000 lives each year

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  • If all eligible US patients were treated to the Systolic Blood Pressure Intervention Trial (SPRINT) targets, a predicted 107,500 lives each year might be saved.
  • But there is a predicted increase in serious adverse events (SAE), including 88,700 cases of acute kidney injury (AKI).

Why this matters  

  • SPRINT famously produced a 27% decrease in mortality in its selected patient population.
  • SPRINT-eligible patient are at high cardiovascular risk but not have stroke, heart failure, or diabetes.
  • About 17 million adults in the US might be eligible, but 9 million are not even being treated for hypertension.
  • Most “real-world” patients do not fit SPRINT criteria.

Study design

  • Mortality and SAE rates in SPRINT-eligible participants (SE; n=2185) from National Health and Nutrition Examination Survey (NHANES) were evaluated and predictions calculated for patients with criteria for SPRINT-applied (SA).
  • Funding: None.

Key results

  • Overall mo...