We screened 279 studies on Influenza and Pneumonia this month. These are the most important.
Prevention of acute respiratory infections: "a major new indication for vitamin D supplementation"
- Meta-analysis of 25 randomized controlled trials including 11,000 patients found that daily or weekly supplementation with vitamin D significantly reduced the risk for acute respiratory infection.
- The effect was seen particularly, but not only, in people with very low baseline levels.
Influenza antivirals: largest study to date confirms safety in pregnancy
- Population-based, multinational, observational cohort study and meta-analysis finds no increased risk for adverse neonatal outcomes with exposure to neuraminidase inhibitors during pregnancy.
- Study involved 5824 exposed and 692,232 unexposed infants.
Antimicrobial stewardship: Cochrane review concludes it works
- Systematic review of 221 studies (58 randomized) finds that interventions are effective in safely reducing unnecessary antibiotic use in hospitalized patients.
- Both enabling and restricting interventions were independently associated with increased antibiotic policy compliance.
Pneumonia: even isolated rib fractures pose significant risk
- Pneumonia is common after multiple rib fractures and has been strongly associated with mortality.
- Although the incidence of pneumonia after isolated minor rib fractures was low, patients had almost 9-fold the risk compared with control patients.
Other recent Vitals: