Influenza and Pneumonia Vitals for March 2017

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We screened 279 studies on Influenza and Pneumonia this month. These are the most important.


Prevention of acute respiratory infections: "a major new indication for vitamin D supplementation"

Source: BMJ



  • Meta-analysis of 25 randomized controlled trials including 11,000 patients found that daily or weekly supplementation with vitamin D significantly reduced the risk for acute respiratory infection.
  • The effect was seen particularly, but not only, in people with very low baseline levels.

 

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Influenza antivirals: largest study to date confirms safety in pregnancy

Source: BMJ



  • Population-based, multinational, observational cohort study and meta-analysis finds no increased risk for adverse neonatal outcomes with exposure to neuraminidase inhibitors during pregnancy.
  • Study involved 5824 exposed and 692,232 unexposed infants.

 

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Antimicrobial stewardship: Cochrane review concludes it works

Source: Cochrane Database Syst Rev


 

  • Systematic review of 221 studies (58 randomized) finds that interventions are effective in safely reducing unnecessary antibiotic use in hospitalized patients.
  • Both enabling and restricting interventions were independently associated with increased antibiotic policy compliance.

 

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Pneumonia: even isolated rib fractures pose significant risk

Source: BMJ



  • Pneumonia is common after multiple rib fractures and has been strongly associated with mortality.
  • Although the incidence of pneumonia after isolated minor rib fractures was low, patients had almost 9-fold the risk compared with control patients.

 

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Previous Vitals on Influenza and Pneumonia: February '17January '17

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