Influenza vaccine in pregnancy: no increase in birth defect risk?
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- Large observational study shows no increased risk for major structural birth defects in offspring after maternal first trimester inactivated influenza vaccine (IIV) vaccination.
Why this matters
- Data should provide reassurance for women considering first trimester vaccination.
- Observational study.
- Pregnant women with live-born singletons at 7 Vaccine Safety Datalink sites.
- Infants followed for 1 y.
- First trimester IIV exposure defined as receipt before 14 wk of gestation.
- Primary outcome was presence of 1 or more of more than 50 prespecified major structural birth defects.
- Funding: CDC.
- 425,944 mother–infant pairs, of whom 12% received first trimester IIV (exposed).