Iron supplementation not helpful for iron deficiency in HFrEF
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- 16 wk of high-dose oral iron supplementation does nothing for exercise capacity and has minimal effects on iron stores in patients with heart failure with reduced ejection fraction (HFrEF).
Why this matters
- About half of patients with HFrEF have iron deficiency, which predicts decreasing functional capacity and mortality.
- Iron would have been an inexpensive way to help these patients.
- None of the exercise-related endpoints improved with iron supplementation (peak O2 change, 6-min walk, and biomarkers).
- No differences between men and women.
- No differences based on baseline features or symptoms.
- The IRONOUT double-blind, placebo-controlled...