Iron supplementation not helpful for iron deficiency in HFrEF

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  • 16 wk of high-dose oral iron supplementation does nothing for exercise capacity and has minimal effects on iron stores in patients with heart failure with reduced ejection fraction (HFrEF).

Why this matters  

  • About half of patients with HFrEF have iron deficiency, which predicts decreasing functional capacity and mortality.
  • Iron would have been an inexpensive way to help these patients.

Key results 

  • None of the exercise-related endpoints improved with iron supplementation (peak O2 change, 6-min walk, and biomarkers).
  • No differences between men and women.
  • No differences based on baseline features or symptoms.

Study design

  • The IRONOUT double-blind, placebo-controlled...