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KRAS-mutated colorectal cancer: adagrasib with or without cetuximab shows promise

Miriam Davis, PhD | Clinical Summary | 11 January 2023

The KRYSTAL-1 clinical trial finds 19%-46% objective response rate.

Background

KRAS is the most frequently mutated oncogene in human cancer, including colorectal cancer.
Adagrasib was recently approved by the US Food and Drug Administration for advanced non-small cell lung cancer.
Adagrasib is a highly targeted, orally acting inhibitor of the mutant KRAS G12C protein ( KRAS G12C refers to a...

Colorectal Cancer

Gastroenterology

General Medicine

Genomic Medicine

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