Liver transplants: risk of death because of increasing donor age highest in young recipients | EASL

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Takeaway

  • The risk of death after liver transplantation (LT) because of increasing donor age is highest in young recipients. 

Why this matters

  • Efforts should be made to allocate the best organs to younger LT candidates. 

Key results

  • Of the 63,628 LTs performed, 4174 (6.6%) were in recipients <40 years, of which 2145 (51.4%) used a donor <40 y.
  • Only 7.5% (2145/27,855) of all donor organs <40 y were transplanted in age-matched recipients <40 y.
  • The proportion of recipients ≥60 y more than doubled during the study period, from 21.1% in 2002 to 44.7% in 2015.
  • Three- and 5-year survival rates for recipients <40 vs ≥60 years were 86.8% vs 77.9% and 81.2% vs 70%, respectively.
  • The effect of increasing donor age on survival was less in recipients <40 vs ≥60 y.
  • The interaction of recipient and donor age was significant in unadjusted and unadjusted models (P<.001).
  • The adjusted risk of death in recipi...