- A previous cancer diagnosis does not affect survival in patients with locally advanced lung cancer, and these patients should receive appropriate treatment and not be automatically excluded from clinical trials.
- Retrospective database study using Surveillance, Epidemiology, and End Results-Medicare linked data set and 51,542 patients aged 65 y and older with locally advanced lung cancer were identified.
- 15.8% had a history of prior cancer, with prostate (25%), gastrointestinal (17%), breast (16%), and other genitourinary (15%) the most common cancers noted.
- About half (54%) of prior cancers were diagnosed a median of 4.5 y of the index lung cancer date.
- Those with prior cancer had similar (propensity-score adjusted HR, 0.96; 95% CI, 0.94-0.99; P=.005) and improved lung cancer-specific (HR, 0.84; 95% CI, 0.81-0.86; P<.001) survival vs patients without a previous cancer history.
- In a subset of pa...