Lung cancer: prior cancer diagnosis does not impact survival

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  • A previous cancer diagnosis does not affect survival in patients with locally advanced lung cancer, and these patients should receive appropriate treatment and not be automatically excluded from clinical trials.
Study design
  • Retrospective database study using Surveillance, Epidemiology, and End Results-Medicare linked data set and 51,542 patients aged 65 y and older with locally advanced lung cancer were identified.
  • 15.8% had a history of prior cancer, with prostate (25%), gastrointestinal (17%), breast (16%), and other genitourinary (15%) the most common cancers noted.
Key results
  • About half (54%) of prior cancers were diagnosed a median of 4.5 y of the index lung cancer date.
  • Those with prior cancer had similar (propensity-score adjusted HR, 0.96; 95% CI, 0.94-0.99; P=.005) and improved lung cancer-specific (HR, 0.84; 95% CI, 0.81-0.86; P<.001) survival vs patients without a previous cancer history.
  • In a subset of pa...